Resistance Pattern Of Pseudomonas Aeruginosa In Tertiary Care Hospitalised Patients

Abstract

Background: The hospitals are burdened with a high frequency of nosocomial infections often caused by multiresistant nosocomial pathogens. Pseudomonas aeruginosa has emerged as one of the most problematic Gram-negative pathogens. Despite advances in medical and surgical care and introduction of wide variety of antimicrobial agents against having anti-pseudomonas activities. Objective(s): The present study aimed to investigate the frequency of Pseudomonas aeruginosa from the various clinical samples in Nawaz Sharif Social Security hospital,Lahore and to investigate resistance patterns against various antibiotics widely used for treatment. Methodology: A cross-sectional study is conducted at Nawaz Sharif Social Society hospital, Lahore from June 1 to September 30, 2024. A total of 99 patients who were suspected of bloodstream, burn, Ear discharge, sputum, urinary tract or surgical site nosocomial infections were enrolled consecutively. Specimens were collected and processed following standard microbiological procedures. Results: The study comprised 99 patients including male and female with all ages. A total of 55 males and 44 females are included. The highest percentages for both genders lie in the 21-40 age group, with 39% males and 14% females. The frequency and percentage distribution of different specimen types collected, with the most common being Right Ear Swab (39%), followed by Left Ear Swab (28%). Wound Swab, Sputum, and Puss accounted for 12%, 8%, and 7% of the specimens, respectively. Blood Culture and Right Bronchial tr were the least common, each representing 5% and 2% of the total, respectively. Conclusion(s): The susceptibility patterns of isolates to various antimicrobial agents. A significant proportion of isolates were resistant to Ampicillin (83%) and Cefepime (51%), indicating high resistance to these drugs. In contrast, Imipenem + Meropenem demonstrated the highest sensitivity (85%), suggesting its potential effectiveness in treating infections caused by these isolates. Tobramycin, Piperacillin + Tazobactam, and Ceftazidime showed intermediate levels of resistance and sensitivity, with a notable proportion of isolates displaying neither sensitivity nor resistance to these agents.

Keywords: Pseudomonas aeruginosa, Multiresistance, Gram-negative, Ampicillin, Tobramycin, Piperacillin + Tazobactam