Formulation Development And Enhancement Solubility Of Poorly Water Soluble Drug Montelukast By Solid Self-Emulsifying Drugs Delivery Systems (SEDDSs)

Abstract

Self-emulsifying drug-delivery systems (SEDDSs) are designed to enhance the oral bioavailability of montelukast which is a poorly water-soluble drug. This study aimed at formulating and characterization of SEDDS-based tablets for montelukast using Oleic acid as solvent, Tween 20 as a surfactant and PEG 400 as a co surfactant because they exhibited maximum solubility for montelukast. Based on solubility studies liquids SEDDS were produced by using different ratios of oil, surfactant and co surfactant.  The formulated liquid SEDDS were adsorbed on aerosil 200 and all the formulations were subsequently compressed to produce tablets. The tablets produced by SEDDS were tested for different quality control parameters at pre and post compression levels. The tablets produced were physically in good shape and free of any evidence of physical abnormalities. The results of all pre compression and post compression tests were all within limits and according to USP guidelines. The results of different quality control tests evaluated the possibility of formulating SEDDS tablets of montelukast. Thus by formulating SEDDS tablets will eliminate the problem of poor absorption of lipophilic and enhances the bioavailability of class II BCS drugs.

Keywords: Montelukast; self emulsyfiying drug delivery system; oleic acid, Tween 20; PEG 40.